Polyacrylamide gel electrophoretic and immunochemical studies on urinary proteins in Sjögren's syndrome, with special reference to tubular proteinuria.

SAITO, H., FURUYAMA, T., SHIOJI, R., ONODERA, S., SASAKI, Y. and ITO, H. Polyacrylamide Gel Electrophoretic and Immunochemical Studies on Urinary Proteins in Sjogren's Syndrome, with Special Reference to Tubular Proteinuria. Tohoku J. exp. Med., 1970, 101 (3), 205-214Polyacrylamide gel electrophoretic and immunochemical studies were carried out on urine proteins in Sjogren's syndrome with definite renal tubular dysfunction. Proteinuria showed a distinctive tubular pattern, namely, a small albumin fraction less than 20 %, of total urinary proteins, two or three distinct bands in a-region, and post y-protein. Proteinuria disap peared completely, when metabolic acidosis and hypokalemia were controlled by the administration of alkaline agents, and reappeared in parallel with recurrent metabolic acidosis and hypokalemia after the cessation of treatment, while renal tubular dysfunction persisted during treatment. The effect of metabolic acidosis and/or hypokalemia on defective renal tubular reabsorption of proteins is discus sed. The values of relatve 1gG clearance were significantly increased in Sjogren's syndrome compared with those in chronic glomerulonephritis. It seems to suggest increased urinary excretion of low molecular weight protein antigenically related closely to serum 1gG, and also to give another evidence of tubular proteinuria in Sjogren's syndrome. Sjogren's syndrome; polyacrylamide gel electrophore sis ; urinary protein ; tubular proteinuria